Robert K Semple Selected Research

Donohue Syndrome

1/2014	Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations.
1/2012	A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure.
8/2007	IGF-I treatment of insulin resistance.

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Robert K Semple Research Topics

Disease

34	Insulin Resistance 03/2022 - 11/2004
14	Lipodystrophy 11/2022 - 03/2006
10	Type 2 Diabetes Mellitus (MODY) 11/2022 - 11/2004
9	Fatty Liver 03/2022 - 02/2009
8	Obesity 11/2022 - 11/2007
7	Neoplasms (Cancer) 01/2022 - 06/2012
6	Dyslipidemias (Dyslipidemia) 01/2020 - 11/2004
5	Hypoglycemia (Reactive Hypoglycemia) 01/2021 - 05/2009
4	Hyperinsulinism (Hyperinsulinemia) 11/2020 - 04/2010
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2017 - 03/2006
3	Acanthosis Nigricans 03/2022 - 01/2007
3	Hyperandrogenism 01/2021 - 01/2007
3	Hyperglycemia 11/2020 - 11/2018
3	Hypertriglyceridemia 01/2017 - 02/2009
3	Dwarfism 10/2015 - 02/2008
3	Donohue Syndrome 01/2014 - 08/2007
3	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2010 - 03/2009
3	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 01/2009 - 01/2007
2	Werner Syndrome (Werner's Syndrome) 09/2022 - 01/2020
2	Non-alcoholic Fatty Liver Disease 01/2022 - 08/2010
2	Vascular Malformations 11/2018 - 01/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2018 - 07/2017
2	Coronary Artery Disease (Coronary Atherosclerosis) 12/2017 - 06/2011
2	Weight Loss (Weight Reduction) 10/2017 - 05/2015
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2017 - 06/2011
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2017 - 10/2013
2	Endometrial Neoplasms (Endometrial Cancer) 09/2015 - 08/2013
2	Genetic Risk Score 12/2014 - 10/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Gallstones (Gallstone) 01/2022
1	Tuberous Sclerosis (Bourneville's Disease) 01/2021
1	Hypopigmentation (Hypomelanosis) 01/2021
1	Connective Tissue Diseases (Connective Tissue Disease) 08/2020
1	Psoriatic Arthritis 08/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 08/2020
1	Mixed Connective Tissue Disease (MCTD) 08/2020
1	Bloom Syndrome 01/2020
1	And Genital Anomalies Adrenal Hypoplasia Congenita Metaphyseal Dysplasia Intrauterine Growth Retardation 12/2018
1	Hypoxia (Hypoxemia) 01/2018
1	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 12/2017
1	Familial Partial Lipodystrophy (Dunnigan Syndrome) 10/2017
1	Alstrom Syndrome 07/2017
1	Deafness (Deaf Mutism) 07/2017
1	Bardet-Biedl syndrome 2 07/2017
1	Retinal Dystrophies 07/2017
1	Fibrosis (Cirrhosis) 07/2017

Drug/Important Bio-Agent (IBA)

40	Insulin (Novolin)FDA Link 11/2022 - 03/2007
19	Insulin ReceptorIBA 11/2020 - 06/2007
11	Glucose (Dextrose)FDA LinkGeneric 11/2020 - 01/2007
11	AdiponectinIBA 12/2017 - 06/2007
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2008
8	Triglycerides (Triacylglycerol)IBA 03/2022 - 01/2009
7	HDL CholesterolIBA 01/2022 - 11/2004
6	AntibodiesIBA 01/2021 - 06/2007
6	LipidsIBA 10/2020 - 03/2006
5	B-insulinIBA 08/2020 - 06/2007
4	LeptinIBA 11/2022 - 01/2007
4	AutoantibodiesIBA 08/2020 - 05/2015
3	Pharmaceutical PreparationsIBA 01/2022 - 11/2017
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2015
3	Phosphotransferases (Kinase)IBA 11/2017 - 10/2016
3	Neurokinin BIBA 01/2010 - 03/2009
2	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2013
2	C-PeptideIBA 01/2021 - 10/2018
2	Metformin (Glucophage)FDA LinkGeneric 08/2020 - 01/2020
2	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2019 - 11/2017
2	Rosiglitazone (Avandia)FDA Link 01/2018 - 11/2004
2	2,4-thiazolidinedione (thiazolidinedione)IBA 01/2018 - 11/2004
2	Nonsense Codon (Nonsense Mutation)IBA 12/2017 - 08/2009
2	Nonesterified Fatty Acids (NEFA)IBA 01/2017 - 08/2010
2	Sex Hormone-Binding GlobulinIBA 12/2014 - 05/2008
2	CalciumIBA 12/2014 - 01/2014
2	DNA (Deoxyribonucleic Acid)IBA 06/2012 - 01/2009
2	Insulin-Like PeptidesIBA 01/2012 - 05/2010
2	pericentrinIBA 03/2011 - 02/2008
2	Insulin-Like Growth Factor I (IGF-1)IBA 05/2010 - 08/2007
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	HDL LipoproteinsIBA 01/2022
1	SilverIBA 01/2022
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2021
1	Testosterone (Sustanon)FDA Link 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2020
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 08/2020
1	Methotrexate (Mexate)FDA LinkGeneric 08/2020
1	Ketone BodiesIBA 01/2020
1	Acarbose FDA LinkGeneric 01/2020
1	DNA HelicasesIBA 01/2020
1	Dietary Carbohydrates (Carbohydrate, Dietary)IBA 01/2020
1	Starch (Cornstarch)IBA 01/2020
1	DNA Polymerase IIIBA 12/2018
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2018
1	Monoclonal AntibodiesIBA 01/2018
1	EpitopesIBA 01/2018
1	Monomeric GTP-Binding ProteinsIBA 12/2017
1	AndrogensIBA 01/2017

Therapy/Procedure

11	Therapeutics 11/2022 - 11/2004
1	Diet Therapy (Therapy, Diet) 01/2020
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 10/2017
1	Glycemic Control 10/2017